DEPO-MEDROL (methylprednisolone) is a corticosteroid that can be used to treat conditions such as joint pain caused by an injury, or flares of pain associated with osteoarthritis (OA).

Do not take DEPO-MEDROL if you are allergic to any of its ingredients.

DEPO-MEDROL should not be used in premature infants, or in systemic fungal infections.

Do not stop using DEPO-MEDROL abruptly or without the approval of your doctor. You should also tell any doctors that you see that you are taking a corticosteroid. If you develop a fever or other signs of infection, you should call a doctor right away.

When taking DEPO-MEDROL you should avoid exposure to chicken pox or measles. If you think you were exposed, you should call a doctor immediately.

DEPO-MEDROL may mask some signs of infection, and new infections may appear during its use.

These infections may be mild, but can be severe and at times fatal. With increasing doses of DEPO-MEDROL, the rate of occurrence of infectious complications increases. Injection of DEPO-MEDROL may result in changes in the skin at the injection site like dips or dents. Prolonged use of corticosteroids may produce eye damage. Average and large doses of corticosteroids can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium.

As with all corticosteroids, DEPO-MEDROL has been associated with allergic skin reactions, erythema, and tendon rupture. Hyperglycemia, osteoporosis, psychiatric disorders, myopathy, and the stunting of growth may also occur.

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